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Chapter seven

Key trends for 2000 and beyond


Dr Alan Lopez: Tobacco is unique in its killing ability


r Alan Lopez of the WHO argues that by 2020 tobacco will be the main cause of death in the world. Through his research Lopez has amassed much evidence of the unique nature of the public health hazard resulting from tobacco use. But getting the message across to decision-makers and individual smokers themselves is a another question.

...the real impact of tobacco needs to be understood better.

Dr Lopez is an epidemiologist and programme manager for the World Health Organization. He is also responsible for the WHO programme on substance abuse, which comprises all activities dealing with addictive substance addiction involving tobacco, alcohol and illicit drugs.

Dr Lopez says that the real impact of tobacco needs to be understood better. He has recently been studying morbidity, disability and death in different populations throughout the world, and together with Richard Peto is preparing the second edition on Mortality from Smoking in Developed Countries. The first edition, now sold out, covered the period 1950-2000.

Alarming trend for decades

The Peto-Lopez study reaffirmed that tobacco is a killer. And it stays a killer, according to recent study findings by Lopez and Dr. Christopher J.L. Murray, Harvard professor of international health economics. The conclusions of a nearly five-year study by the Harvard School of Public Health, World Health Organization and the World Bank entitled the Global Burden of Disease show that noncommunicable diseases and accidents are rapidly replacing diseases and malnutrition as the primary cause of death the world over.

The study estimates that by 2020 over eight million will die annually from smoking-related illnesses, compared to the current figure of three million. Murray and Lopez noted that the extraordinary epidemic of tobacco-related mortality and disability emerges as the most alarming trend over the next three decade.

"We are going from three million deaths to 8-9 million deaths in couple of decades. We can see changes in how these deaths occur", says Lopez. "Other causes of death are declining: we are succeeding in bringing down malaria, tuberculosis and HIV. By 2020 tobacco will be the single largest cause of death, and the single largest public health problem in the world. It will cause more deaths than measles, complications of childbirth and HIV combined. This needs to be better understood."

Figures, accuracy and projection

Lopez argues that major public health risks has to be quantified by the scientific community in order to get independent, objective information. But how accurate are the projections of tobacco-related deaths worldwide?

"There has been the evaluation by tobacco industry, which of course is very negative and critical. Richard Peto and I claimed in our book that in the rich countries of the world--Europe, North America, Australia, and so on -tobacco kills about two million people a year. The tobacco industry claims that this is exaggerated, but they still admit that tobacco is killing a large number of people. It might even be killing more than two million a year.

"On the other hand, the book has been widely received and used by the advocates of the tobacco control community. This is what the book was for--it is not a detailed scientific book in the sense one would expect. All the science and methods were published earlier in The Lancet. This book was an attempt to take that science and translate it into actual tables, numbers, figures so that people in Finland, Lithuania or Spain could use it and show policy makers the impact count--the past impact and more importantly the projected impact of tobacco if we don't do anything about it.

"Richard Peto and I are now beginning to work with the second edition. It will use the 1995 data as an index, as our first edition used the 1990 data. By the time we get to work on this, we plan to look at the 1995 data. That would give us even more accurate projections of the future."

Numbers are relatively consistent

"More recently I have been involved with the World Bank and Harvard University on the much larger study called The Global Burden of Disease. This attempts to quantify the mortality and morbidity rate in over a hundred diseases and injuries and the risk factors, including tobacco. Professor Murray and I made projections of tobacco deaths up until 2020 by region, age, sex and cause--which is a very detailed compilation. The instruments are similar to the ones Professor Peto and I used. Earlier work suggested that tobacco will kill about ten million people a year in 2020«s or early 2030«s. Professor Murray and I estimate that in 2020 the number will already be about 8-81/2 million, so these numbers are relatively consistent."

Lung cancer and baseline data

"The method Professor Peto and I developed is really related to ignoring what classical epidemiology has done. Classical epidemiology takes prevalence--let«s say smoking in Finland--and relates it to a set of relative risks. Peto and I said that the whole history of countries smoking epidemic is in their lung cancer rate. If you subtract a little bit of the lung cancer rate due to background factors that the smokers and non-smokers are likely to experience, anything left is likely to be due to smoking. We then scaled the set of relative risks like heart diseases, chronic lung diseases and all the cancers and we look an the country's lung cancer rate. As a result of looking at it, we can make a decision of the proportion of other diseases that should also be attributed to tobacco. If the male lung cancer rate is high, then it is likely that the other diseases caused by tobacco are also high. Baseline data is very important to these projections. In many countries lung cancer rates are coming down. This means that the tobacco deaths will also be falling."

Trouble shooting with the World Bank

Future projections also give the tobacco control community a pretty clear picture of the future trouble spots. Tobacco-related diseases develop slowly, and the statistical projections are about 30 years behind the real situation. Scientists such as Lopez work hard to ensure the projected future never arrives. They also urge decision-makers to rely more on this evidence-based health policy, as they call it.

WHO has in recent years collaborated with the World Bank and the European Union.

Lopez says that the big issue WHO would like to see happen in Europe is a ban on advertising and promotion of tobacco products within the European Union.

Working with the World Bank has been fruitful because the tobacco agenda goes far beyond health issues.

"Questions related to economic aspects and development are completely outside the WHO mandate. We need to forge partnerships with major international organizations. Our collaboration with the World Bank on economic aspects of tobacco has been successful. The World Bank now has very restrictive policies on loans for tobacco production, and is not only refusing to lend money for tobacco products but also becoming more actively involved with WHO in research and information. Countries need to be convinced that tobacco actually is far more greater cause of economic loss than it is of economic gain."

Adult mortality, tobacco and eastern Europe

WHO focuses on tobacco issues in Central and Eastern Europe and not only in EU Europe. Lopez describes the situation in these large areas of the continent as "alarming".

"Take Hungary. You have levels of lung cancer in middle-aged men which exceed the highest level ever recorded in the United Kingdom--which had by far the worst lung cancer epidemic from tobacco. And the lung cancer rates in Hungary are still on the rise. There are many other countries in Central and Eastern Europe, where the situation is perhaps not as alarming, but nevertheless very worrying.

"Tobacco consumption is showing no sign of declining. On top of this we have a very active effort by tobacco industry to promote tobacco goods under the guise of freedom of lifestyle. The new political environment appears tremendously explosive and potentially dangerous in terms of public health care."

Lopez says that the levels of adult mortality among men in Central and Eastern Europe are unlikely to decline during the next couple of decades.

"Adult mortality may even rise because of the massive tobacco epidemic that is already present in these countries. Tobacco consumption levels are very high. This is probably the region in the world, along with China, about which WHO is the most concerned. Yes, tobacco is public health enemy number one."

"...if you start smoking in your teenage years and continue to do so systemically, you will have about a 50 per cent chance of being killed by tobacco."

Dr. Lopez is often asked whether tobacco is really more of a health risk than illicit drugs from WHO`s point of view. Lopez has both a short answer and a longer explanation.

"Yes, tobacco is a far greater risk than drugs or alcohol. Unquestionably alcohol and drugs cause a lot of social disruption, whereas tobacco simply kills you. This is the issue society has to deal with: can we afford to tolerate the degrees of sickness and premature deaths that arise from an addiction that is an extremely effective killer? People need to understand that tobacco is no like other hazard. It is unique in its ability to kill you.

"The studies we have had coming from different populations all show, if you start smoking in your teenage years and continue to do so systemically, you will have about a 50 per cent chance of being killed by tobacco. There is no other exposure or addiction that produces that sort of risk, with the single exception of HIV.

"The tobacco industry is likely to argue that there are other mortal risks people face, such as getting struck by a lightning or getting run down by a car. But these risks are much smaller than those posed by tobacco. We must, as societies, and as public health organizations, focus the attention of people and governments on the fact that the risk from tobacco is like no other public health concern.

"While alcohol abuse is a major cause for social disruption and premature mortality, the projected epidemic of alcohol abuse is not nearly as alarming as the projections we have concerning tobacco. I am not saying that we should minimize alcohol as a public health concern, but it is of a different nature. Similarly, drugs kill people, the related risk of HIV is high, and drugs are a cause of violence. But in terms of their public health impact drugs are a far less of a substantial problem than tobacco, or for that matter alcohol."

Looking to the future

Lopez describes his vision of the trends and challenges that lie ahead.

1. Better communications

"Although we have the necessary information, many people, especially politicians, have other agendas. "

"We have the information, but we still need a far more effective communication mechanism. We are making the projections but have not been effective in communicating them to policy makers and to smokers themselves. Although we have the necessary information, many people, especially politicians, have other agendas."

2. Cessation

"A lot of people die from tobacco use. They are not only old people, but also the middle-aged. Exposure to tobacco is most likely to be problematic when you are a teenager.In addition, young people are often rebellious and like to experiment. Tobacco is an easy legal substance to experiment with. Tobacco cessation has to be far more effective means to young adults, who already are addicted to tobacco."

3. Prevention

"A major concern of WHO has been to prevent tobacco use among young people. The social environment is crucial. Countries are using legislative mechanism to prevent smoking and this has a snowball effect. The more you restrict the places and possibilities to use tobacco, the less people will smoke."

4. Changing attitudes

"Very important changes in general attitudes towards tobacco use have come about, for instance in the United States and Finland. Two or three decades ago, smoking was socially acceptable behaviour. Now, it is socially abnormal behaviour. Society itself is taking steps to supporting legislative measures. Individual smokers are reminded that smoking is a hazardous habit."

5. Smoking is additive behaviour

"There is an important trend in WHO: smoking is being viewed as addictive behaviour, as is cocaine or heroin use, or alcohol consumption. This approach deals with smoking in the social context. Besides the physiological and psychological aspects, smokers will be increasingly associated with the issue of addiction. Certain attributes are being increasingly linked to addictive behaviour, such as weakness and disappointment. This brings in the societal reaction to tobacco."

6. Women

Passive smoking is the question the tobacco industry is probably mostly concerned about. The industry does not want passive smoking to become a major public health issue, because it could entail massive legal implications.

"The tobacco epidemic among males is not on the rise. But what we are likely to see in the future is a rapid rise of smoking-related deaths among women. It is important to ensure women and girls in developing countries smokefree lives."

7. Passive smoking

"This is the question the tobacco industry is probably mostly concerned about. The industry does not want passive smoking to become a major public health issue, because it could entail massive legal implications. I believe that scientific work on environmental tobacco smoke will be considerably strengthened." n

Interview by Satu Lipponen


Smoke Free Europe - A Forum for Networks - 14 AUG 1997
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