UICC GLOBALink Presents...
The Tobacco Reference Guide
by David Moyer, MD.


Chapter 11 Other health problems

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Other health problems: Depression and Psychiatric Problems

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Seriously depressed young people are more likely than others to become daily

smokers, and the tobacco habit itself can also raise the risk of depression. A study

from Case Western Reserve University in Cleveland published in the February 1998

issue of the Archives of General Psychiatry concluded that the link between smoking

and depression is a "two way street."

San Francisco Chronicle, February 12, 1998, p. A3

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An estimated 30-40% of people who begin smoking cessation programs are

depressed, or about three times the rate of depression in nonsmokers. In another

study, 74% of patients with schizophrenia smoked.

Cigarettes, p. 114

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About a third of smokers have a history of major depression, compared with a lifetime

prevalence of 10% to 15% in the general population. They tend to have only about half

the success rate in smoking cessation as do smokers without a history of

depression. 75% of smokers with a history of major depression developed

depressive symptoms during withdrawal, which quickly disappeared when the patient

returned to smoking. 30% of smokers without a positive history of depression

developed these symptoms during withdrawal. In a St. Louis epidemiologic study,

major depression was more than twice as common in smokers, and 76% of subjects

with a history of depression had ever smoked, compared to 52% without a history of

depression.

Mayo Clinic Nicotine Dependence Conference (Paul Frederickson, M.D.), May 13,

1997, and Journal of Clinical Psychiatry, October 1996, p. 468

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Research suggest that cigarette smoke inhibits the activity of monoamine oxidase B

(MAOB); this inhibition may lead to a rise in the brain levels of phenylethylamine, a

neuroactive compound linked to schizophrenia as well as other psychiatric disorders.

Reuters Medical News, October 7, 1997

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Thursday, July 06, 2000 Page 7 of 32

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