Chapter 22 Smoking and tobacco cessation

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Smoking and tobacco cessation: Nicotine replacement and

pharmacologic treatment

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In a study from the Mayo Clinic, nicotine patch therapy plus minimal behavioral

intervention was ineffective for smoking cessation in adolescent smokers; the 6-month

successful abstinence rate was only 5%.

Archives of Pediatric and Adolescent Medicine, January 2000, p. 35

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Nicotine replacement via patch, nasal spray, and inhaler are equally effective, but

compliance is much higher with the patch.

Archives of Internal Medicine, September 27, 1999, p. 2033

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Combining nicotine patch therapy with nicotine gum or nasal spray or inhalers, or

combining patch with bupropion, may increase smoking cessation rates compared

with any single treatment.

JAMA, January 6, 1999, pp. 72-76

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In a study from Iceland, use of nicotine nasal spray combined with the nicotine patch

was a more effective method of stopping smoking than use of a patch only.

British Medical Journal 318:285, 1999

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Over the counter nicotine patch therapy is effective for smoking cessation; active

patch users have double the cessation rates over placebo control subjects in most

clinical trials. In a study from the Mayo Clinic of nicotine patch therapy without behavior

modification treatment, smoking cessation rates were 18.4% and 11.0% at 12 weeks

(end of patch therapy) and 26 weeks, respectively. This compared to 7.0% and 4.2%

cessation rates at 12 and 26 weeks in the placebo groups.

American Journal of Public Health, November 1999, pp. 1701-1706

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Thursday, July 06, 2000

Page 20 of 25

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